Calle 10 is the main street, but most of the food and entertainment in El Poblado is situated around Parque Lleras. You will find many very good restaurants in this area from traditional Colombian food to international fare. This small park is the place to be on weekends. Up and down the crowded streets there are several bars and clubs to choose from with all kinds of music.
During the day, El Poblado is much quieter. There isn’t much in the way of tourism. Parque Lleras is a much more tame without all the traffic and noise. You might find a few street vendors selling crafts of sombreros, but not much else.
A few blocks away, Parque El Poblado is a nice little park with places to sit. The park has a small monument to mark the founding of Medellín in 1616. On one corner is the Iglesia San José del Poblado.
El Poblado is a bit far from the city center. The metro stop Poblado is about a 10 minute walk from the main part of the area. At night, it might be safer to take a taxi from the metro. During the day, it’s perfectly safe to walk. Also, if you aren’t staying in the area, when leaving the bars at night, it may be very difficult to find a taxi if it is raining.