My DNA Analysis by Doug McDonald

After enthusiastically receiving the results from my DNA test and uploading them to GEDmatch, I sent away my 23andMe raw data to Dr. Doug McDonald, a former professor at the University of Illinois, for further analysis. This was the result:

Most likely fit is 45.0% (+/- 17.3%) Europe (various subcontinents) and 55.0% (+/- 17.3%) Mideast (various subcontinents).

The following are possible population sets and their fractions, most likely at the top:
Tuscan= 0.547     Cypriot= 0.453
Tuscan= 0.657     Armenian= 0.343
Tuscan= 0.698     Druze= 0.302
French= 0.307     Cypriot= 0.693
English= 0.261     Cypriot= 0.739
Germany= 0.252     Cypriot= 0.748
Italian= 0.430     Cypriot= 0.570

all which is very typical for Greeks. Nothing at all unusual. We don’t have Greeks as comparison panels.

The results were much more surprising than what I had gotten with 23andMe. With this analysis, it showed 55% Middle Eastern and 45% European with a 17.3% margin of error. I wasn’t expecting such a huge jump in Middle Eastern from 15.6% in my 23andMe results.

The possible population sets represent the most probable makeup of my ancestry. All of them make sense except for the French, English, and German.

The following image also shows some interesting data. The first is a map indicating the average location of ancestry. The green dot is the average location of overall ancestry (Greece). The blue dot is the average location of Middle Eastern ancestry (Cyprus). The red dot is the average location of European ancestry (Italy), which if looked at closely seems to be right on top of Venice. This makes a lot of sense to me because my ancestral home of Chios in Greece was for a short time under the rule of the Republic of Venice before being ruled by the Genoese for nearly 250 years. It was also a part of the Roman Empire for a very long time.

Map plot

Map plot

The next two images show a scatter plot which indicates average ancestry across my entire genome. In both, I show up in Sicily.

Scatter plot

Scatter plot

Scatter plot

Scatter plot

The final image shows a color-coded chromosome segment painting. It shows location data for all 22 autosomes and the X chromosome. This is where the percentages of Middle Eastern and European were determined along with the margin of error. There are a couple blue dots indicating Africa, but Dr. McDonald believes this is probably just “noise”.

Chromosome segment painting

Chromosome segment painting

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